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Farnesyl Diphosphate Synthase Inhibitors With Unique Ligand-Binding Geometries
[Image: see text] Farnesyl diphosphate synthase (FPPS) is an important drug target for bone resorption, cancer, and some infectious diseases. Here, we report five new structures including two having unique bound ligand geometries. The diamidine inhibitor 7 binds to human FPPS close to the homoallyli...
Tallennettuna:
| Julkaisussa: | ACS Med Chem Lett |
|---|---|
| Päätekijät: | , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Chemical
Society
2015
|
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4360152/ https://ncbi.nlm.nih.gov/pubmed/25815158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500528x |
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