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Head-to-Head Prenyl Tranferases: Anti-Infective Drug Targets
We report x-ray crystallographic structures of three inhibitors bound to dehydrosqualene synthase from Staphylococcus aureus: 1 (BPH-651), 2 (WC-9) and 3 (SQ-109). Compound 2 binds to the S2 site with its –SCN group surrounded by 4 hydrogen bond donors. With 1, we report two structures: in both, the...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3349777/ https://ncbi.nlm.nih.gov/pubmed/22486710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300208p |
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