“Head-to-head” Prenyl Synthases in Some Pathogenic Bacteria

Many organisms contain “head-to-head” isoprenoid synthases and here, we investigate three types of such enzymes from the pathogens Neisseria meningitidis, N. gonorrhoeae, and Enterococcus hirae. The E. hirae enzyme was found to produce dehydrosqualene and we solved an inhibitor-bound structure which...

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Detalhes bibliográficos
Publicado no:Chembiochem
Principais autores: Schwalen, Christopher J., Feng, Xinxin, Liu, Weidong, O-Dowd, Bing, Ko, Tzu-Ping, Shin, Christopher J., Guo, Rey-Ting, Mitchell, Douglas A., Oldfield, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5569891/
https://ncbi.nlm.nih.gov/pubmed/28340291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201700099
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