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“Head-to-head” Prenyl Synthases in Some Pathogenic Bacteria

Many organisms contain “head-to-head” isoprenoid synthases and here, we investigate three types of such enzymes from the pathogens Neisseria meningitidis, N. gonorrhoeae, and Enterococcus hirae. The E. hirae enzyme was found to produce dehydrosqualene and we solved an inhibitor-bound structure which...

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Foilsithe in:Chembiochem
Main Authors: Schwalen, Christopher J., Feng, Xinxin, Liu, Weidong, O-Dowd, Bing, Ko, Tzu-Ping, Shin, Christopher J., Guo, Rey-Ting, Mitchell, Douglas A., Oldfield, Eric
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5569891/
https://ncbi.nlm.nih.gov/pubmed/28340291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201700099
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