Moenomycin Biosynthesis: Structure and Mechanism of Action of the Prenyl Transferase MoeN5

We report the structure of MoeN5, a unique prenyl transferase involved in moenomycin biosynthesis. MoeN5 catalyzes the reaction of geranyl diphosphate (GPP) with the cis-farnesyl group in phosphoglycolipid 5 to form the (C(25)) moenocinyl sidechain-containing lipid 7. GPP binds to an allylic site (S...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Zhang, Lilan, Chen, Chun-Chi, Ko, Tzu-Ping, Huang, Jian-Wen, Zheng, Yingying, Liu, Weidong, Wang, Iren, Malwal, Satish R., Feng, Xinxin, Wang, Ke, Huang, Chun-Hsiang, Hsu, Shang-Te Danny, Wang, Andrew H.-J., Oldfield, Eric, Guo, Rey-Ting
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4818699/
https://ncbi.nlm.nih.gov/pubmed/26954060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201511388
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