HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis

[Image: see text] We report the discovery of antibacterial leads, keto- and diketo-acids, targeting two prenyl transferases: undecaprenyl diphosphate synthase (UPPS) and dehydrosqualene synthase (CrtM). The leads were suggested by the observation that keto- and diketo-acids bind to the active site M...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Principais autores: Zhang, Yonghui, Lin, Fu-Yang, Li, Kai, Zhu, Wei, Liu, Yi-Liang, Cao, Rong, Pang, Ran, Lee, Eunhae, Axelson, Jordan, Hensler, Mary, Wang, Ke, Molohon, Katie J., Wang, Yang, Mitchell, Douglas A., Nizet, Victor, Oldfield, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3363326/
https://ncbi.nlm.nih.gov/pubmed/22662288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300038t
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registros relacionados