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Isoprenoid Biosynthesis Inhibitors Targeting Bacterial Cell Growth

We synthesized potential inhibitors of farnesyl diphosphate synthase (FPPS), undecaprenyl diphosphate synthase (UPPS) or undecaprenyl diphosphate phosphatase (UPPP), and tested them in bacterial cell growth and enzyme inhibition assays. The most active compounds were bisphosphonates with electron-wi...

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Publicado en:ChemMedChem
Main Authors: Desai, Janish, Wang, Yang, Wang, Ke, Malwal, Satish R., Oldfield, Eric
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5160999/
https://ncbi.nlm.nih.gov/pubmed/27571880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201600343
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