Antibacterial drug leads targeting isoprenoid biosynthesis

With the rise in resistance to antibiotics such as methicillin, there is a need for new drugs. We report here the discovery and X-ray crystallographic structures of 10 chemically diverse compounds (benzoic, diketo, and phosphonic acids, as well as a bisamidine and a bisamine) that inhibit bacterial...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Zhu, Wei, Zhang, Yonghui, Sinko, William, Hensler, Mary E., Olson, Joshua, Molohon, Katie J., Lindert, Steffen, Cao, Rong, Li, Kai, Wang, Ke, Wang, Yang, Liu, Yi-Liang, Sankovsky, Anna, de Oliveira, César Augusto F., Mitchell, Douglas A., Nizet, Victor, McCammon, J. Andrew, Oldfield, Eric
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2013
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538244/
https://ncbi.nlm.nih.gov/pubmed/23248302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1219899110
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires