HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis

[Image: see text] We report the discovery of antibacterial leads, keto- and diketo-acids, targeting two prenyl transferases: undecaprenyl diphosphate synthase (UPPS) and dehydrosqualene synthase (CrtM). The leads were suggested by the observation that keto- and diketo-acids bind to the active site M...

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Bibliographische Detailangaben
Hauptverfasser: Zhang, Yonghui, Lin, Fu-Yang, Li, Kai, Zhu, Wei, Liu, Yi-Liang, Cao, Rong, Pang, Ran, Lee, Eunhae, Axelson, Jordan, Hensler, Mary, Wang, Ke, Molohon, Katie J., Wang, Yang, Mitchell, Douglas A., Nizet, Victor, Oldfield, Eric
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2012
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3363326/
https://ncbi.nlm.nih.gov/pubmed/22662288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300038t
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