Inducible DNA breaks in Ig S regions are dependent on AID and UNG

Por Schrader, Carol E., Linehan, Erin K., Mochegova, Sofia N., Woodland, Robert T., Stavnezer, Janet
Publicado em 2005

DNA polymerases β and λ do not directly affect Ig variable region somatic hypermutation although their absence reduces the frequency of mutations

Por Schrader, Carol E., Linehan, Erin K., Ucher, Anna J., Bertocci, Barbara, Stavnezer, Janet
Publicado em 2013

Nbs1 ChIP-Seq Identifies Off-Target DNA Double-Strand Breaks Induced by AID in Activated Splenic B Cells

Por Khair, Lyne, Baker, Richard E., Linehan, Erin K., Schrader, Carol E., Stavnezer, Janet
Publicado no PLoS Genet (2015)

Individual Substitution Mutations in the AID C Terminus That Ablate IgH Class Switch Recombination

Por Kadungure, Tatenda, Ucher, Anna J., Linehan, Erin K., Schrader, Carol E., Stavnezer, Janet
Publicado no PLoS One (2015)

The DNA Glycosylases Ogg1 and Nth1 Do Not Contribute to Ig Class Switching in Activated Mouse Splenic B Cells

Por Ucher, Anna J., Linehan, Erin K., Teebor, George W., Schrader, Carol E., Stavnezer, Janet
Publicado em 2012

AID binds cooperatively with UNG and Msh2-Msh6 to Ig switch regions dependent upon the AID C terminus()

Por Ranjit, Sanjay, Khair, Lyne, Linehan, Erin K., Ucher, Anna J., Chakrabarti, Mrinmay, Schrader, Carol E., Stavnezer, Janet
Publicado em 2011

AP endonuclease 2 regulates the expansion of germinal centers by protecting against AID-independent DNA damage in B cells()

Por Guikema, Jeroen E.J., Linehan, Erin K., Esa, Nada, Tsuchimoto, Daisuke, Nakabeppu, Yusaku, Woodland, Robert T., Schrader, Carol E.
Publicado em 2014

APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination

Por Guikema, Jeroen E.J., Linehan, Erin K., Tsuchimoto, Daisuke, Nakabeppu, Yusaku, Strauss, Phyllis R., Stavnezer, Janet, Schrader, Carol E.
Publicado em 2007

APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination

Por Guikema, Jeroen E.J., Linehan, Erin K., Tsuchimoto, Daisuke, Nakabeppu, Yusaku, Strauss, Phyllis R., Stavnezer, Janet, Schrader, Carol E.
Publicado em 2007

Reassessment of the Role of Mut S Homolog 5 in Ig Class Switch Recombination Shows Lack of Involvement in cis- and trans-Switching

Por Guikema, Jeroen E. J., Schrader, Carol E., Leus, Niek G. J., Ucher, Anna, Linehan, Erin K., Werling, Uwe, Edelmann, Winfried, Stavnezer, Janet
Publicado em 2008

Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation

Por Stavnezer, Janet, Linehan, Erin K., Thompson, Mikayla R., Habboub, Ghaith, Ucher, Anna J., Kadungure, Tatenda, Tsuchimoto, Daisuke, Nakabeppu, Yusaku, Schrader, Carol E.
Publicado em 2014

AP-Endonuclease 2 is necessary for normal B cell development and recovery of lymphoid progenitors after chemotherapeutic challenge

Por Guikema, Jeroen E.J., Gerstein, Rachel M., Linehan, Erin K., Cloherty, Erin K., Evan-Browning, Eric, Tsuchimoto, Daisuke, Nakabeppu, Yusaku, Schrader, Carol E.
Publicado em 2011

Mismatch repair proteins and AID deaminase activity are required for the dominant negative function of C terminally-deleted AID in class switching

Por Ucher, Anna J., Ranjit, Sanjay, Kadungure, Tatenda, Linehan, Erin K., Khair, Lyne, Xie, Elaine, Limauro, Jennifer, Rauch, Katherina S., Schrader, Carol E., Stavnezer, Janet
Publicado em 2014

ATM increases AID activity at downstream S regions during class switch recombination

Por Khair, Lyne, Guikema, Jeroen E.J., Linehan, Erin K., Ucher, Anna J., Leus, Niek G.J., Ogilvie, Colin, Lou, Zhenkun, Schrader, Carol E., Stavnezer, Janet
Publicado em 2014

p53 Represses Class Switch Recombination to IgG2a through its Antioxidant Function

Por Guikema, Jeroen E.J., Schrader, Carol E., Brodsky, Michael H., Linehan, Erin K., Richards, Adam, El Falaky, Nahla, Li, Daniel H., Sluss, Hayla K., Szomolanyi-Tsuda, Eva, Stavnezer, Janet
Publicado em 2010