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Individual Substitution Mutations in the AID C Terminus That Ablate IgH Class Switch Recombination
Activation-induced cytidine deaminase (AID) is essential for class switch recombination (CSR) and somatic hypermutation (SHM) of Ig genes. The C terminus of AID is required for CSR but not for SHM, but the reason for this is not entirely clear. By retroviral transduction of mutant AID proteins into...
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| Publicado no: | PLoS One |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4534307/ https://ncbi.nlm.nih.gov/pubmed/26267846 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134397 |
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