ATM increases AID activity at downstream S regions during class switch recombination

Activation-induced cytidine deaminase (AID) initiates antibody class switch recombination (CSR) in activated B cells resulting in exchanging the IgH constant region and improved antibody effector function. During CSR, AID instigates DNA double strand break (DSB) formation in switch (S) regions locat...

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Main Authors: Khair, Lyne, Guikema, Jeroen E.J., Linehan, Erin K., Ucher, Anna J., Leus, Niek G.J., Ogilvie, Colin, Lou, Zhenkun, Schrader, Carol E., Stavnezer, Janet
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4049217/
https://ncbi.nlm.nih.gov/pubmed/24729610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1303481
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