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APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination
Antibody class switch recombination (CSR) occurs by an intrachromosomal deletion requiring generation of double-stranded breaks (DSBs) in switch-region DNA. The initial steps in DSB formation have been elucidated, involving cytosine deamination by activation-induced cytidine deaminase and generation...
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| Asıl Yazarlar: | , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
The Rockefeller University Press
2007
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2118529/ https://ncbi.nlm.nih.gov/pubmed/18025127 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20071289 |
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