AP endonuclease 2 regulates the expansion of germinal centers by protecting against AID-independent DNA damage in B cells()

Activation-induced cytidine deaminase (AID()) initiates a process generating DNA mutations and breaks in germinal center (GC) B cells that are necessary for somatic hypermutation and class switch recombination. GC B cells can “tolerate” DNA damage while rapidly proliferating due to partial suppressi...

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Detalhes bibliográficos
Main Authors: Guikema, Jeroen E.J., Linehan, Erin K., Esa, Nada, Tsuchimoto, Daisuke, Nakabeppu, Yusaku, Woodland, Robert T., Schrader, Carol E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4105697/
https://ncbi.nlm.nih.gov/pubmed/24935922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400002
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