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AP endonuclease 2 regulates the expansion of germinal centers by protecting against AID-independent DNA damage in B cells()
Activation-induced cytidine deaminase (AID()) initiates a process generating DNA mutations and breaks in germinal center (GC) B cells that are necessary for somatic hypermutation and class switch recombination. GC B cells can “tolerate” DNA damage while rapidly proliferating due to partial suppressi...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4105697/ https://ncbi.nlm.nih.gov/pubmed/24935922 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400002 |
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