Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation

Somatic hypermutation (SHM) of antibody variable region genes is initiated in germinal center B cells during an immune response by activation-induced cytidine deaminase (AID), which converts cytosines to uracils. During accurate repair in nonmutating cells, uracil is excised by uracil DNA glycosylas...

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Detalhes bibliográficos
Main Authors: Stavnezer, Janet, Linehan, Erin K., Thompson, Mikayla R., Habboub, Ghaith, Ucher, Anna J., Kadungure, Tatenda, Tsuchimoto, Daisuke, Nakabeppu, Yusaku, Schrader, Carol E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4078814/
https://ncbi.nlm.nih.gov/pubmed/24927551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1405590111
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