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Mismatch repair proteins and AID deaminase activity are required for the dominant negative function of C terminally-deleted AID in class switching
Activation-induced cytidine deaminase (AID) is essential for class switch recombination (CSR) and somatic hypermutation (SHM) of Ig genes. The AID C terminus is required for CSR but not for S region DNA DSBs during CSR, and it is not required for SHM. AID lacking the C terminus (ΔAID) is a dominant...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4142545/ https://ncbi.nlm.nih.gov/pubmed/24973444 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400365 |
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