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The DNA Glycosylases Ogg1 and Nth1 Do Not Contribute to Ig Class Switching in Activated Mouse Splenic B Cells

During activation of B cells to undergo class switching, B cell metabolism is increased, and levels of reactive oxygen species (ROS) are increased. ROS can oxidize DNA bases resulting in substrates for the DNA glycosylases Ogg1 and Nth1. Ogg1 and Nth1 excise oxidized bases, and nick the resulting ab...

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Detalhes bibliográficos
Main Authors: Ucher, Anna J., Linehan, Erin K., Teebor, George W., Schrader, Carol E., Stavnezer, Janet
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3334981/
https://ncbi.nlm.nih.gov/pubmed/22536455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036061
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