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Mutations occur in the Ig Sµ region but rarely in Sγ regions prior to class switch recombination

Nucleotide substitutions are found in recombined Ig switch (S) regions and also in unrecombined (germline, GL) Sµ segments in activated splenic B cells. Herein we examine whether mutations are also introduced into the downstream acceptor S regions prior to switch recombination, but find very few mut...

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Detalhes bibliográficos
Main Authors: Schrader, Carol E., Bradley, Sean P., Vardo, Joycelyn, Mochegova, Sofia N., Flanagan, Erin, Stavnezer, Janet
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC275407/
https://ncbi.nlm.nih.gov/pubmed/14592986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg550
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