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Inducible DNA breaks in Ig S regions are dependent on AID and UNG
Class switch recombination (CSR) occurs by an intrachromosomal deletion whereby the IgM constant region gene (Cμ) is replaced by a downstream constant region gene. This unique recombination event involves formation of double-strand breaks (DSBs) in immunoglobulin switch (S) regions, and requires act...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2212854/ https://ncbi.nlm.nih.gov/pubmed/16103411 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050872 |
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