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Role for Mismatch Repair Proteins Msh2, Mlh1, and Pms2 in Immunoglobulin Class Switching Shown by Sequence Analysis of Recombination Junctions

B cells from mice deficient in mismatch repair (MMR) proteins show decreased ability to undergo class switch recombination in vitro and in vivo. The deficit is not accompanied by any reduction in cell viability or alterations in the cell cycle in B cells cultured in vitro. To assess the role of MMR...

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Autori principali: Schrader, Carol E., Vardo, Joycelyn, Stavnezer, Janet
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2002
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193596/
https://ncbi.nlm.nih.gov/pubmed/11828012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20011877
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