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Shifts in targeting of class switch recombination sites in mice that lack μ switch region tandem repeats or Msh2

The mechanisms that target class switch recombination (CSR) to antibody gene switch (S) regions are unknown. Analyses of switch site locations in wild-type mice and in mice that lack the Sμ tandem repeats show shifts indicating that a 4–5-kb DNA domain (bounded upstream by the Iμ promoter) is access...

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Bibliografski detalji
Glavni autori: Min, Irene M., Rothlein, Lisa R., Schrader, Carol E., Stavnezer, Janet, Selsing, Erik
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2005
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212040/
https://ncbi.nlm.nih.gov/pubmed/15955838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20042491
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