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Mutations occur in the Ig Sµ region but rarely in Sγ regions prior to class switch recombination

Nucleotide substitutions are found in recombined Ig switch (S) regions and also in unrecombined (germline, GL) Sµ segments in activated splenic B cells. Herein we examine whether mutations are also introduced into the downstream acceptor S regions prior to switch recombination, but find very few mut...

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Bibliographic Details
Main Authors: Schrader, Carol E., Bradley, Sean P., Vardo, Joycelyn, Mochegova, Sofia N., Flanagan, Erin, Stavnezer, Janet
Format: Artigo
Language:Inglês
Published: Oxford University Press 2003
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC275407/
https://ncbi.nlm.nih.gov/pubmed/14592986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg550
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