The DNA Glycosylases Ogg1 and Nth1 Do Not Contribute to Ig Class Switching in Activated Mouse Splenic B Cells

During activation of B cells to undergo class switching, B cell metabolism is increased, and levels of reactive oxygen species (ROS) are increased. ROS can oxidize DNA bases resulting in substrates for the DNA glycosylases Ogg1 and Nth1. Ogg1 and Nth1 excise oxidized bases, and nick the resulting ab...

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Detaylı Bibliyografya
Asıl Yazarlar: Ucher, Anna J., Linehan, Erin K., Teebor, George W., Schrader, Carol E., Stavnezer, Janet
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2012
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3334981/
https://ncbi.nlm.nih.gov/pubmed/22536455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036061
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