Individual Substitution Mutations in the AID C Terminus That Ablate IgH Class Switch Recombination

Activation-induced cytidine deaminase (AID) is essential for class switch recombination (CSR) and somatic hypermutation (SHM) of Ig genes. The C terminus of AID is required for CSR but not for SHM, but the reason for this is not entirely clear. By retroviral transduction of mutant AID proteins into...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Kadungure, Tatenda, Ucher, Anna J., Linehan, Erin K., Schrader, Carol E., Stavnezer, Janet
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2015
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534307/
https://ncbi.nlm.nih.gov/pubmed/26267846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134397
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