Fluorescence Polarization Assays in Small Molecule Screening

Por Lea, Wendy A., Simeonov, Anton
Publicado em 2011

Differential Scanning Fluorometry Signatures as Indicators of Enzyme Inhibitor Mode of Action: Case Study of Glutathione S-Transferase

Por Lea, Wendy A., Simeonov, Anton
Publicado em 2012

Literature Search and Review

Por Auld, Doug, Simeonov, Anton, Lea, Wendy, Thomas, Craig
Publicado em 2010

Firefly luciferase in chemical biology: A compendium of inhibitors, mechanistic evaluation of chemotypes, and suggested use as a reporter

Por Thorne, Natasha, Shen, Min, Lea, Wendy A., Simeonov, Anton, Lovell, Scott, Auld, Douglas S., Inglese, James
Publicado em 2012

A High-Throughput Approach for Identification of Novel General Anesthetics

Por Lea, Wendy A., Xi, Jin, Jadhav, Ajit, Lu, Louis, Austin, Christopher P., Simeonov, Anton, Eckenhoff, Roderic G.
Publicado em 2009

Identification of phosphotyrosine mimetic inhibitors of Human Tyrosyl-DNA Phosphodiesterase I by a novel AlphaScreen high-throughput assay

Por Marchand, Christophe, Lea, Wendy A., Jadhav, Ajit, Dexheimer, Thomas S, Austin, Christopher P., Inglese, James, Pommier, Yves, Simeonov, Anton
Publicado em 2009

High throughput screen identifies cyclic nucleotide analogs that inhibit Prostatic acid phosphatase

Por McCoy, Eric S., Lea, Wendy A., Mott, Bryan T., Maloney, David J., Jadhav, Ajit, Simeonov, Anton, Zylka, Mark J.
Publicado em 2012

A 1,536-Well-Based Kinetic HTS Assay for Inhibitors of Schistosoma mansoni Thioredoxin Glutathione Reductase

Por Lea, Wendy A., Jadhav, Ajit, Rai, Ganesha, Sayed, Ahmed A., Cass, Cynthia L., Inglese, James, Williams, David L., Austin, Christopher P., Simeonov, Anton
Publicado em 2008

Discovery, SAR, and Biological evaluation of Non-Inhibitory Small Molecule Chaperones of Glucocerebrosidase

Por Patnaik, Samarjit, Zheng, Wei, Choi, Jae H., Motabar, Omid, Southall, Noel, Westbroek, Wendy, Lea, Wendy A., Velayati, Arash, Goldin, Ehud, Sidransky, Ellen, Leister, William, Marugan, Juan J.
Publicado em 2012

Peroxiredoxin-1 from the human hookworm Ancylostoma ceylanicum forms a stable oxidized decamer and is covalently inhibited by conoidin A

Por Nguyen, Jennifer B., Pool, Christopher D., Wong, Christina Y.B., Treger, Rebecca S., Williams, David L., Cappello, Michael, Lea, Wendy A., Simeonov, Anton, Vermeire, Jon J., Modis, Yorgo
Publicado em 2013

Discovery of a Novel General Anesthetic Chemotype Using High-throughput Screening

Por McKinstry-Wu, Andrew R., Bu, Weiming, Rai, Ganesha, Lea, Wendy A., Weiser, Brian P., Liang, David F., Simeonov, Anton, Jadhav, Ajit, Maloney, David J., Eckenhoff, Roderic G.
Publicado no Anesthesiology (2015)

Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124

Por Auld, Douglas S., Lovell, Scott, Thorne, Natasha, Lea, Wendy A., Maloney, David J., Shen, Min, Rai, Ganesha, Battaile, Kevin P., Thomas, Craig J., Simeonov, Anton, Hanzlik, Robert P., Inglese, James
Publicado em 2010

Non-iminosugar glucocerebrosidase small molecule chaperones

Por Marugan, Juan Jose, Huang, Wenwei, Motabar, Omid, Zheng, Wei, Xiao, Jingbo, Patnaik, Samarjit, Southall, Noel, Westbroek, Wendy, Lea, Wendy A., Simeonov, Anton, Goldin, Ehud, DeBernardi, Maria A., Sidransky, Ellen
Publicado em 2011

Evaluation of Quinazoline analogues as Glucocerebrosidase Inhibitors with Chaperone activity

Por Marugan, Juan J., Zheng, Wei, Motabar, Omid, Southall, Noel, Goldin, Ehud, Westbroek, Wendy, K.Stubblefield, Barbara, Sidransky, Ellen, Aungst, Ronald A., Lea, Wendy A., Simeonov, Anton, Leister, William, Austin, Christopher P.
Publicado em 2011

Chaperonin-based biolayer interferometry to assess the kinetic stability of metastable, aggregation-prone proteins

Por Lea, Wendy A., Naik, Subhashchandra, Chaudhri, Tapan, Machen, Alexandra J., O’Neil, Pierce T., McGinn-Straub, Wesley, Tischer, Alexander, Auton, Matthew T., Burns, Joshua R., Baldwin, Michael R., Khar, Karen R., Karanicolas, John, Fisher, Mark T.
Publicado no Biochemistry (2016)

Biochemical, Cellular, and Biophysical Characterization of a Potent Inhibitor of Mutant Isocitrate Dehydrogenase IDH1

Por Davis, Mindy I., Gross, Stefan, Shen, Min, Straley, Kimberly S., Pragani, Rajan, Lea, Wendy A., Popovici-Muller, Janeta, DeLaBarre, Byron, Artin, Erin, Thorne, Natasha, Auld, Douglas S., Li, Zhuyin, Dang, Lenny, Boxer, Matthew B., Simeonov, Anton
Publicado em 2014

Discovery of a novel non-iminosugar acid alpha glucosidase chaperone series

Por Xiao, Jingbo, Westbroek, Wendy, Motabar, Omid, Lea, Wendy A., Hu, Xin, Velayati, Arash, Zheng, Wei, Southall, Noel, Gustafson, Ann Marie, Goldin, Ehud, Sidransky, Ellen, Liu, Ke, Simeonov, Anton, Tamargo, Rafael J., Ribes, Antonia, Matalonga, Leslie, Ferrer, Marc, Marugan, Juan J.
Publicado em 2012

Biochemical assays for the discovery of TDP1 inhibitors

Por Marchand, Christophe, Huang, Shar-yin N., Dexheimer, Thomas S., Lea, Wendy A., Mott, Bryan T., Chergui, Adel, Naumova, Alena, Stephen, Andrew G., Rosenthal, Andrew S., Rai, Ganesha, Murai, Junko, Gao, Rui, Maloney, David J., Jadhav, Ajit, Jorgensen, William L., Simeonov, Anton, Pommier, Yves
Publicado em 2014

Structure-Mechanism Insights and the Role of Nitric Oxide Donation Guide the Development of Oxadiazole-2-Oxides as Therapeutic Agents against Schistosomiasis

Por Rai, Ganesha, Sayed, Ahmed A., Lea, Wendy A., Luecke, Hans, Chakrapani, Harinath, Prast-Nielsen, Stefanie, Jadhav, Ajit, Leister, William, Shen, Min, Inglese, James, Austin, Christopher P., Keefer, Larry, Arnér, Elias S. J., Simeonov, Anton, Maloney, David J., Williams, David L., Thomas, Craig J.
Publicado em 2009

Microscale Thermophoresis Quantifies Biomolecular Interactions under Previously Challenging Conditions

Por Seidel, Susanne A.I., Dijkman, Patricia M., Lea, Wendy A., van den Bogaart, Geert, Jerabek-Willemsen, Moran, Lazic, Ana, Joseph, Jeremiah S., Srinivasan, Prakash, Baaske, Philipp, Simeonov, Anton, Katritch, Ilia, Melo, Fernando A., Ladbury, John E., Schreiber, Gideon, Watts, Anthony, Braun, Dieter, Duhr, Stefan
Publicado em 2012