Biochemical assays for the discovery of TDP1 inhibitors

Drug screening against novel targets is warranted to generate biochemical probes and new therapeutic drug leads. Tyrosyl-DNA-phosphodiesterases 1 and 2 (TDP1 and TDP2) are two DNA repair enzymes that have yet to be successfully targeted. TDP1 repairs topoisomerase I-, alkylation-, and chain terminat...

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Detaylı Bibliyografya
Asıl Yazarlar: Marchand, Christophe, Huang, Shar-yin N., Dexheimer, Thomas S., Lea, Wendy A., Mott, Bryan T., Chergui, Adel, Naumova, Alena, Stephen, Andrew G., Rosenthal, Andrew S., Rai, Ganesha, Murai, Junko, Gao, Rui, Maloney, David J., Jadhav, Ajit, Jorgensen, William L., Simeonov, Anton, Pommier, Yves
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4126877/
https://ncbi.nlm.nih.gov/pubmed/25024006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-0952
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