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Biochemical assays for the discovery of TDP1 inhibitors
Drug screening against novel targets is warranted to generate biochemical probes and new therapeutic drug leads. Tyrosyl-DNA-phosphodiesterases 1 and 2 (TDP1 and TDP2) are two DNA repair enzymes that have yet to be successfully targeted. TDP1 repairs topoisomerase I-, alkylation-, and chain terminat...
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| 主要な著者: | , , , , , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2014
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4126877/ https://ncbi.nlm.nih.gov/pubmed/25024006 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-0952 |
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