Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform

Anti-cancer topoisomerase I (Top1) inhibitors (camptothecin and its clinical derivatives irinotecan and topotecan, and the indenoisoquinolines) induce lethal DNA lesions by stabilizing Top1-DNA cleavage complex (Top1cc). These lesions are repaired by parallel repair pathways including the tyrosyl-DN...

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Main Authors: Murai, Junko, Marchand, Christophe, Shahane, Sampada A., Sun, Hongmao, Huang, Ruili, Zhang, Yiping, Chergui, Adel, Ji, Jiuping, Doroshow, James H., Jadhav, Ajit, Takeda, Shunichi, Xia, Menghang, Pommier, Yves
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125495/
https://ncbi.nlm.nih.gov/pubmed/24794403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2014.03.006
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