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Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2)

TDP1 and TDP2 were discovered and named based on the fact they process 3′- and 5′-DNA ends by excising irreversible protein tyrosyl-DNA complexes involving topoisomerases I and II, respectively. Yet, both enzymes have an extended spectrum of activities. TDP1 not only excises trapped topoisomerases I...

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Detalhes bibliográficos
Main Authors: Pommier, Yves, Huang, Shar-yin N., Gao, Rui, Das, Benu Brata, Murai, Junko, Marchand, Christophe
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4090310/
https://ncbi.nlm.nih.gov/pubmed/24856239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2014.03.020
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