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Role of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria

Human tyrosyl-DNA phosphodiesterase (TDP1) hydrolyzes the phosphodiester bond at a DNA 3′-end linked to a tyrosyl moiety and has been implicated in the repair of topoisomerase I (Top1)-DNA covalent complexes. TDP1 can also hydrolyze other 3′-end DNA alterations including 3′-phosphoglycolate and 3′-a...

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Bibliographic Details
Main Authors: Das, Benu Brata, Dexheimer, Thomas S., Maddali, Kasthuraiah, Pommier, Yves
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2010
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993338/
https://ncbi.nlm.nih.gov/pubmed/21041670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009814107
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