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Tyrosyl-DNA Phosphodiesterase as a Target for Anticancer Therapy

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a recently discovered enzyme that catalyzes the hydrolysis of 3′-phosphotyrosyl bonds. Such linkages form in vivo following the DNA processing activity of topoisomerase I (Top1). For this reason, Tdp1 has been implicated in the repair of irreversible Top1-DN...

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Sonraí Bibleagrafaíochta
Main Authors: Dexheimer, Thomas S., Antony, Smitha, Marchand, Christophe, Pommier, Yves
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2008
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2443942/
https://ncbi.nlm.nih.gov/pubmed/18473723
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