Llwytho...
Discovery of selective inhibitors of tyrosyl-DNA phosphodiesterase 2 by targeting the enzyme DNA-binding cleft
Tyrosyl-DNA phosphodiesterase 2 (TDP2) processes protein/DNA adducts resulting from abortive DNA topoisomerase II (Top2) activity. TDP2 inhibition could provide synergism with the Top2 poison class of chemotherapeutics. By virtual screening of the NCI diversity small molecule database, we identified...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Bioorg Med Chem Lett |
|---|---|
| Prif Awduron: | , , , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2016
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4939481/ https://ncbi.nlm.nih.gov/pubmed/27262595 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.05.065 |
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