Isoquinoline-1,3-diones as Selective Inhibitors of Tyrosyl DNA Phosphodiesterase II (TDP2)

Tyrosyl DNA phosphodiesterase II (TDP2) is a recently discovered enzyme that specifically repairs DNA damages induced by topoisomerase II (Top2) poisons and causes resistance to these drugs. Inhibiting TDP2 is expected to enhance the efficacy of clinically important Top2-targeting anticancer drugs....

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Bibliographic Details
Published in:J Med Chem
Main Authors: Kankanala, Jayakanth, Marchand, Christophe, Abdelmalak, Monica, Aihara, Hideki, Pommier, Yves, Wang, Zhengqiang
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7832085/
https://ncbi.nlm.nih.gov/pubmed/26910725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01973
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