New fluorescence-based high-throughput screening assay for small molecule inhibitors of tyrosyl-DNA phosphodiesterase 2 (TDP2)

Tyrosyl-DNA phosphodiesterase 2 (TDP2) repairs topoisomerase II (TOP2) mediated DNA damages and causes resistance to TOP2-targeted cancer therapy. Inhibiting TDP2 could sensitize cancer cells toward TOP2 inhibitors. However, potent TDP2 inhibitors with favorable physicochemical properties are not ye...

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Pubblicato in:Eur J Pharm Sci
Autori principali: Ribeiro, Carlos J. A., Kankanala, Jayakanth, Shi, Ke, Kurahashi, Kayo, Kiselev, Evgeny, Ravji, Azhar, Pommier, Yves, Aihara, Hideki, Wang, Zhengqiang
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6370590/
https://ncbi.nlm.nih.gov/pubmed/29574079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejps.2018.03.021
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