Synthesis and Biological Evaluation of the First Triple Inhibitors of Human Topoisomerase 1, Tyrosyl–DNA Phosphodiesterase 1 (Tdp1), and Tyrosyl–DNA Phosphodiesterase 2 (Tdp2)

Tdp1 and Tdp2 are two tyrosyl–DNA phosphodiesterases that can repair damaged DNA resulting from topoisomerase inhibitors and a variety of other DNA-damaging agents. Both Tdp1 and Tdp2 inhibition could hypothetically potentiate the cytotoxicities of topoisomerase inhibitors. This study reports the su...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Med Chem
Egile Nagusiak: Wang, Ping, Elsayed, Mohamed S. A., Plescia, Caroline B., Ravji, Azhar, Redon, Christophe E., Kiselev, Evgeny, Marchand, Christophe, Zeleznik, Olga, Agama, Keli, Pommier, Yves, Cushman, Mark
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8170834/
https://ncbi.nlm.nih.gov/pubmed/28418653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b01565
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