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Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents

Tyrosyl–DNA phosphodiesterase 1 (TDP1) is a recently discovered enzyme repairing DNA lesions resulting from stalled topoisomerase IB (TOP1)–DNA covalent complex. Inhibiting TDP1 in conjunction with TOP1 inhibitors can boost the action of the latter. Herein, we report the discovery of the natural pro...

詳細記述

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書誌詳細
出版年:J Med Chem
主要な著者: Zhang, Xiao-Ru, Wang, Hao-Wen, Tang, Wen-Lin, Zhang, Yu, Yang, Hui, Hu, De-Xuan, Ravji, Azhar, Marchand, Christophe, Kiselev, Evgeny, Ofori-Atta, Kwabena, Agama, Keli, Pommier, Yves, An, Lin-Kun
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8085681/
https://ncbi.nlm.nih.gov/pubmed/30336023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00639
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