Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents

Tyrosyl–DNA phosphodiesterase 1 (TDP1) is a recently discovered enzyme repairing DNA lesions resulting from stalled topoisomerase IB (TOP1)–DNA covalent complex. Inhibiting TDP1 in conjunction with TOP1 inhibitors can boost the action of the latter. Herein, we report the discovery of the natural pro...

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Gepubliceerd in:J Med Chem
Hoofdauteurs: Zhang, Xiao-Ru, Wang, Hao-Wen, Tang, Wen-Lin, Zhang, Yu, Yang, Hui, Hu, De-Xuan, Ravji, Azhar, Marchand, Christophe, Kiselev, Evgeny, Ofori-Atta, Kwabena, Agama, Keli, Pommier, Yves, An, Lin-Kun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8085681/
https://ncbi.nlm.nih.gov/pubmed/30336023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00639
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