Novel Deazaflavin Tyrosyl-DNA Phosphodiesterase 2 (TDP2) Inhibitors

gan Kiselev, Evgeny, Ravji, Azhar, Kankanala, Jayakanth, Xie, Jiashu, Wang, Zhengqiang, Pommier, Yves
Cyhoeddwyd yn DNA Repair (Amst) (2019)

New fluorescence-based high-throughput screening assay for small molecule inhibitors of tyrosyl-DNA phosphodiesterase 2 (TDP2)

gan Ribeiro, Carlos J. A., Kankanala, Jayakanth, Shi, Ke, Kurahashi, Kayo, Kiselev, Evgeny, Ravji, Azhar, Pommier, Yves, Aihara, Hideki, Wang, Zhengqiang
Cyhoeddwyd yn Eur J Pharm Sci (2018)

Novel deazaflavin analogues potently inhibited tyrosyl DNA phosphodiesterase 2 (TDP2) and strongly sensitized cancer cells toward treatment with topoisomerase II (TOP2) poison etop...

gan Kankanala, Jayakanth, Ribeiro, Carlos J. A., Kiselev, Evgeny, Ravji, Azhar, Williams, Jessica, Xie, Jiashu, Aihara, Hideki, Pommier, Yves, Wang, Zhengqiang
Cyhoeddwyd yn J Med Chem (2019)

Synthesis and Biological Evaluation of the First Triple Inhibitors of Human Topoisomerase 1, Tyrosyl–DNA Phosphodiesterase 1 (Tdp1), and Tyrosyl–DNA Phosphodiesterase 2 (Tdp2)

gan Wang, Ping, Elsayed, Mohamed S. A., Plescia, Caroline B., Ravji, Azhar, Redon, Christophe E., Kiselev, Evgeny, Marchand, Christophe, Zeleznik, Olga, Agama, Keli, Pommier, Yves, Cushman, Mark
Cyhoeddwyd yn J Med Chem (2017)

Design and Synthesis of Chlorinated and Fluorinated 7-Azaindenoisoquinolines as Potent Cytotoxic Anticancer Agents That Inhibit Topoisomerase I

gan Elsayed, Mohamed S. A., Su, Yafan, Wang, Ping, Sethi, Taresh, Agama, Keli, Ravji, Azhar, Redon, Christophe E., Kiselev, Evgeny, Horzmann, Katharine A., Freeman, Jennifer L., Pommier, Yves, Cushman, Mark
Cyhoeddwyd yn J Med Chem (2017)

Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumo...

gan Zhang, Xiao-Ru, Wang, Hao-Wen, Tang, Wen-Lin, Zhang, Yu, Yang, Hui, Hu, De-Xuan, Ravji, Azhar, Marchand, Christophe, Kiselev, Evgeny, Ofori-Atta, Kwabena, Agama, Keli, Pommier, Yves, An, Lin-Kun
Cyhoeddwyd yn J Med Chem (2018)

Synthesis and Structure-Activity Relationship of Furoquinolinediones as Inhibitors of Tyrosyl-DNA Phosphodiesterase 2 (TDP2)

gan Yu, Le-Mao, Hu, Zhu, Chen, Yu, Ravji, Azhar, Lopez, Sophia, Plescia, Caroline B., Yu, Qian, Yang, Hui, Abdelmalak, Monica, Saha, Sourav, Agama, Keli, Kiselev, Evgeny, Marchand, Christophe, Pommier, Yves, An, Lin-Kun
Cyhoeddwyd yn Eur J Med Chem (2018)