Synthesis and Structure-Activity Relationship of Furoquinolinediones as Inhibitors of Tyrosyl-DNA Phosphodiesterase 2 (TDP2)

Tyrosyl-DNA phosphodiesterase 2 (TDP2) is a recently discovered enzyme specifically repairing topoisomerase II (TOP2)-mediated DNA damage. It has been shown that inhibition of TDP2 synergize with TOP2 inhibitors. Herein, we report the discovery of the furoquinolinedione chemotype as a suitable skele...

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Bibliographic Details
Published in:Eur J Med Chem
Main Authors: Yu, Le-Mao, Hu, Zhu, Chen, Yu, Ravji, Azhar, Lopez, Sophia, Plescia, Caroline B., Yu, Qian, Yang, Hui, Abdelmalak, Monica, Saha, Sourav, Agama, Keli, Kiselev, Evgeny, Marchand, Christophe, Pommier, Yves, An, Lin-Kun
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5930004/
https://ncbi.nlm.nih.gov/pubmed/29677635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.04.024
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