Novel deazaflavin analogues potently inhibited tyrosyl DNA phosphodiesterase 2 (TDP2) and strongly sensitized cancer cells toward treatment with topoisomerase II (TOP2) poison etoposide

Topoisomerase II (TOP2) poisons as anticancer drugs work by trapping TOP2 cleavage complexes (TOP2cc) to generate DNA damage. Repair of such damage by tyrosyl DNA phosphodiesterase 2 (TDP2) could render cancer cells resistant to TOP2 poisons. Inhibiting TDP2 thus represents an attractive mechanism-b...

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Publicado no:J Med Chem
Main Authors: Kankanala, Jayakanth, Ribeiro, Carlos J. A., Kiselev, Evgeny, Ravji, Azhar, Williams, Jessica, Xie, Jiashu, Aihara, Hideki, Pommier, Yves, Wang, Zhengqiang
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6624171/
https://ncbi.nlm.nih.gov/pubmed/30998359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00274
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