Novel deazaflavin analogues potently inhibited tyrosyl DNA phosphodiesterase 2 (TDP2) and strongly sensitized cancer cells toward treatment with topoisomerase II (TOP2) poison etoposide

Topoisomerase II (TOP2) poisons as anticancer drugs work by trapping TOP2 cleavage complexes (TOP2cc) to generate DNA damage. Repair of such damage by tyrosyl DNA phosphodiesterase 2 (TDP2) could render cancer cells resistant to TOP2 poisons. Inhibiting TDP2 thus represents an attractive mechanism-b...

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Detaylı Bibliyografya
Yayımlandı:J Med Chem
Asıl Yazarlar: Kankanala, Jayakanth, Ribeiro, Carlos J. A., Kiselev, Evgeny, Ravji, Azhar, Williams, Jessica, Xie, Jiashu, Aihara, Hideki, Pommier, Yves, Wang, Zhengqiang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6624171/
https://ncbi.nlm.nih.gov/pubmed/30998359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00274
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