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Isoquinoline-1,3-diones as Selective Inhibitors of Tyrosyl DNA Phosphodiesterase II (TDP2)

Tyrosyl DNA phosphodiesterase II (TDP2) is a recently discovered enzyme that specifically repairs DNA damages induced by topoisomerase II (Top2) poisons and causes resistance to these drugs. Inhibiting TDP2 is expected to enhance the efficacy of clinically important Top2-targeting anticancer drugs....

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Detalles Bibliográficos
Publicado en:J Med Chem
Main Authors: Kankanala, Jayakanth, Marchand, Christophe, Abdelmalak, Monica, Aihara, Hideki, Pommier, Yves, Wang, Zhengqiang
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7832085/
https://ncbi.nlm.nih.gov/pubmed/26910725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01973
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