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The DNA binding and 3′-end preferential activity of human tyrosyl-DNA phosphodiesterase
Human tyrosyl-DNA phosphodiesterase (Tdp1) processes 3′-blocking lesions, predominantly 3′-phosphotyrosyl bonds resulting from the trapping of topoisomerase I (Top1) cleavage complexes. The controversial ability of yeast Tdp1 to hydrolyze 5′-phosphotyrosyl linkage between topoisomerase II (Top2) and...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2853120/ https://ncbi.nlm.nih.gov/pubmed/20097655 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1206 |
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