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Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2)
TDP1 and TDP2 were discovered and named based on the fact they process 3′- and 5′-DNA ends by excising irreversible protein tyrosyl-DNA complexes involving topoisomerases I and II, respectively. Yet, both enzymes have an extended spectrum of activities. TDP1 not only excises trapped topoisomerases I...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4090310/ https://ncbi.nlm.nih.gov/pubmed/24856239 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2014.03.020 |
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