Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2·DNA and Top2·RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2)

Eukaryotic type II topoisomerases (Top2α and Top2β) are homodimeric enzymes; they are essential for altering DNA topology by the formation of normally transient double strand DNA cleavage. Anticancer drugs (etoposide, doxorubicin, and mitoxantrone) and also Top2 oxidation and DNA helical alterations...

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Библиографические подробности
Главные авторы: Gao, Rui, Schellenberg, Matthew J., Huang, Shar-yin N., Abdelmalak, Monica, Marchand, Christophe, Nitiss, Karin C., Nitiss, John L., Williams, R. Scott, Pommier, Yves
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2014
Предметы:
DNA and Chromosomes
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140274/
https://ncbi.nlm.nih.gov/pubmed/24808172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.565374
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