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Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage

Agents targeting topoisomerases are active against a wide range of human tumors. Stabilization of covalent complexes, converting topoisomerases into DNA-damaging agents, is an essential aspect of cell killing by these drugs. A unique aspect of the repair of topoisomerase-mediated DNA damage is the r...

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Detalhes bibliográficos
Main Authors: Nitiss, Karin C., Malik, Mobeen, He, Xiaoping, White, Stephen W., Nitiss, John L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1482547/
https://ncbi.nlm.nih.gov/pubmed/16751265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603455103
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