Rationale for Poly(ADP-ribose) Polymerase (PARP) Inhibitors in Combination Therapy with Camptothecins or Temozolomide Based on PARP Trapping versus Catalytic Inhibition

We recently showed that poly(ADP-ribose) polymerase (PARP) inhibitors exert their cytotoxicity primarily by trapping PARP-DNA complexes in addition to their NAD(+)-competitive catalytic inhibitory mechanism. PARP trapping is drug-specific, with olaparib exhibiting a greater ability than veliparib, w...

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Hlavní autoři: Murai, Junko, Zhang, Yiping, Morris, Joel, Ji, Jiuping, Takeda, Shunichi, Doroshow, James H., Pommier, Yves
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2014
Témata:
Chemotherapy, Antibiotics, and Gene Therapy
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019318/
https://ncbi.nlm.nih.gov/pubmed/24650937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.210146
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