Stereospecific PARP trapping by BMN 673 and comparison with olaparib and rucaparib

Anti-poly(ADP-ribose)polymerase (PARP) drugs were initially developed as catalytic inhibitors to block the repair of DNA single-strand breaks. We recently reported that several PARP inhibitors have an additional cytotoxic mechanism by trapping PARP-DNA complexes, and that both olaparib and niraparib...

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Detalhes bibliográficos
Main Authors: Murai, Junko, Huang, Shar-yin N., Renaud, Amèlie, Zhang, Yiping, Ji, Jiuping, Takeda, Shunichi, Morris, Joel, Teicher, Beverly, Doroshow, James H., Pommier, Yves
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946062/
https://ncbi.nlm.nih.gov/pubmed/24356813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-0803
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