Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate

Base excision repair (BER) represents the most important repair pathway of endogenous DNA lesions. Initially, a base damage is recognized, excised and a DNA single-strand break (SSB) intermediate forms. The SSB is then ligated, a process that employs proteins also involved in SSB repair, e.g. XRCC1,...

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Bibliographische Detailangaben
Hauptverfasser: Ström, Cecilia E., Johansson, Fredrik, Uhlén, Mathias, Szigyarto, Cristina Al-Khalili, Erixon,  Klaus, Helleday, Thomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2011
Schlagworte:
Genome Integrity, Repair and Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3082910/
https://ncbi.nlm.nih.gov/pubmed/21183466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq1241
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