Poly(ADP-ribose) polymerases covalently modify strand break termini in DNA fragments in vitro

Poly(ADP-ribose) polymerases (PARPs/ARTDs) use nicotinamide adenine dinucleotide (NAD(+)) to catalyse the synthesis of a long branched poly(ADP-ribose) polymer (PAR) attached to the acceptor amino acid residues of nuclear proteins. PARPs act on single- and double-stranded DNA breaks by recruiting DN...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Talhaoui, Ibtissam, Lebedeva, Natalia A., Zarkovic, Gabriella, Saint-Pierre, Christine, Kutuzov, Mikhail M., Sukhanova, Maria V., Matkarimov, Bakhyt T., Gasparutto, Didier, Saparbaev, Murat K., Lavrik, Olga I., Ishchenko, Alexander A.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2016
Assuntos:
Genome Integrity, Repair and Replication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5100588/
https://ncbi.nlm.nih.gov/pubmed/27471034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw675
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