Characterization of DNA ADP-ribosyltransferase activities of PARP2 and PARP3: new insights into DNA ADP-ribosylation

Poly(ADP-ribose) polymerases (PARPs) act as DNA break sensors and catalyze the synthesis of polymers of ADP-ribose (PAR) covalently attached to acceptor proteins at DNA damage sites. It has been demonstrated that both mammalian PARP1 and PARP2 PARylate double-strand break termini in DNA oligonucleot...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Zarkovic, Gabriella, Belousova, Ekaterina A, Talhaoui, Ibtissam, Saint-Pierre, Christine, Kutuzov, Mikhail M, Matkarimov, Bakhyt T, Biard, Denis, Gasparutto, Didier, Lavrik, Olga I, Ishchenko, Alexander A
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2018
Soggetti:
Genome Integrity, Repair and Replication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5861426/
https://ncbi.nlm.nih.gov/pubmed/29361132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1318
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